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Mutation Information
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Mutation Site
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L66P |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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P12 |
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Country
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Caribbean; France; North America; Africa; Brazil |
Literature Information
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PubMed PMID
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27553711
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Disease
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HTLV-1 associated myelopathy/tropical spastic paraparesis
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Published Year
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2016 |
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Journal
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Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
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Title
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Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome. |
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Author
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Barreto FK,Khouri R,Rego FFA,Santos LA,Castro-Amarante MF,Bialuk I,Pise-Masison CA,Galvão-Castro B,Gessain A,Jacobson S,Franchini G,Alcantara LC Jr |
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Evidence
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We selected the most frequent natural mutations within ORF-I sequences (F3L, S23P, D26N, G29S, P34L, C39R, L40F, P45L, F61L, S63P, L66P, S69G, R83C, R88K and P91S) to evaluate their possible association with the development of HAM/TSP using the Excel program.
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HTLV1 Mutation Detail Information