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Mutation Information
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Mutation Site
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L64A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Vpr |
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Genotype/Subtype
|
G |
Literature Information
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PubMed PMID
|
32753492
|
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Published Year
|
2020 |
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Journal
|
mBio |
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Title
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HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. |
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Author
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Li D,Lopez A,Sandoval C,Nichols Doyle R,Fregoso OI |
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Evidence
|
We selected two mutants that have been previously shown to alter HIV-1 Vpr binding to DCAF1, L64A and H71R, and further generated those mutants in HIV-2 Vpr (L69A and H76R, respectively).
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HIV Mutation Detail Information