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Mutation Information
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Mutation Site
|
L648C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E1 |
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Genotype/Subtype
|
HPV18 |
|
Viral Reference
|
NC_001357.1
|
|
Country
|
China |
Literature Information
|
PubMed PMID
|
23451059
|
|
Disease
|
Cervical carcinoma
|
|
Published Year
|
2013 |
|
Journal
|
PloS one |
|
Title
|
Sequence variation analysis of HPV-18 isolates in southwest China. |
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Author
|
Shen M,Ding X,Li T,Chen G,Zhou X |
|
Evidence
|
As shown in Fig. 1A, DNA sequence analysis of the HPV-18 E1 region revealed the following four variations: a T to G transversion at nt2856 and a G to C transversion at nt2857 leading to a L648C AA substitution (n = 18, 32.1%), and a C to G transversion at nt2858 and a G to T transversion at nt2859 leading to a R649V AA change (n = 18, 32.1%).
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HPV Mutation Detail Information