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Mutation Information
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Mutation Site
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L63P |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
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PubMed PMID
|
30051611
|
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Published Year
|
2018 |
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Journal
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Molecular informatics |
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Title
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Flap-site Fragment Restores Back Wild-type Behaviour in Resistant Form of HIV Protease. |
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Author
|
Luchi A,Angelina E,Bogado L,Forli S,Olson A,Peruchena N |
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Evidence
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Thus, these point mutations (i.e L63P and V77I) seem to increase the strength of the interactions among different segments of the protease thus preventing the clockwise/anti-clockwise movement of flap elbows necessary for a correlated motion of both flaps tips.
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HIV Mutation Detail Information