|
Mutation Information
|
Mutation Site
|
L63P |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
atazanavir (ATV) |
Literature Information
|
PubMed PMID
|
29763303
|
|
Published Year
|
2018 |
|
Journal
|
Journal of medicinal chemistry |
|
Title
|
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. |
|
Author
|
Ghosh AK,R Nyalapatla P,Kovela S,Rao KV,Brindisi M,Osswald HL,Amano M,Aoki M,Agniswamy J,Wang YF,Weber IT,Mitsuya H |
|
Evidence
|
The amino acid substitutions identified in the protease-encoding region compared to the wild-type HIV-1NL4-3 were L23I, E34Q, K43I, M46I, I50L, G51A, L63P, A71V, V82A, T91A in HIV-1ATVR5μM; L10F, M46I, I54V, V82A in HIV-1LPVR5μM; or L10F, M46I, I50V, I85V in HIV-1APVR5μM.
|
|
|
HIV Mutation Detail Information