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Mutation Information
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Mutation Site
|
L63P |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
|
PubMed PMID
|
25362963
|
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Published Year
|
2014 |
|
Journal
|
Scientific reports |
|
Title
|
Revealing origin of decrease in potency of darunavir and amprenavir against HIV-2 relative to HIV-1 protease by molecular dynamics simulations. |
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Author
|
Chen J,Liang Z,Wang W,Yi C,Zhang S,Zhang Q |
|
Evidence
|
Mutations that confer major resistance in PR1, such as G48V, L63P and I84V weaken or do not present these interactions46, which basically agrees with our studies here.
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HIV Mutation Detail Information