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HIV Mutation Detail Information

> L63I Search Result


Mutation Information
Mutation Site L63I
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Literature Information
PubMed PMID 18597780
Published Year 2008
Journal Journal of molecular biology
Title Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
Author Liu F,Kovalevsky AY,Tie Y,Ghosh AK,Harrison RW,Weber IT
Evidence RESULTS AND DISCUSSIONThe wild type HIV-1 PR in these studies contains mutations Q7K, L33I, and L63I to diminish autoproteolysis and C67A and C95A to prevent cysteine-thiol oxidation, and showed almost identical kinetic parameters, stability and dimer dissociation as the unmutated wild type PR.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation