|
Mutation Information
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Mutation Site
|
L61A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E6 |
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Genotype/Subtype
|
HPV8 |
Literature Information
|
PubMed PMID
|
30875834
|
|
Published Year
|
2019 |
|
Journal
|
Cells |
|
Title
|
The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene. |
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Author
|
Taute S,Böhnke P,Sprissler J,Buchholz S,Hufbauer M,Akgül B,Steger G |
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Evidence
|
The P40A, V70A and L63A/W65A mutants in HPV5E6, which correspond to P38A, L61A/W63A and V68A in HPV8E6, respectively, lost completely their activity to induce the degradation of Bak, but still partially inhibited apoptosis [52], indicating that other activities than targeting Bak may contribute to HV8E6-mediated inhibition of UV-induced apoptosis.
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HPV Mutation Detail Information