|
Mutation Information
|
Mutation Site
|
L60A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpr |
|
Combined Mutation
|
vpr.L67A+vpr.L60A |
Literature Information
|
PubMed PMID
|
10620603
|
|
Published Year
|
2000 |
|
Journal
|
The Journal of experimental medicine |
|
Title
|
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. |
|
Author
|
Jacotot E,Ravagnan L,Loeffler M,Ferri KF,Vieira HL,Zamzami N,Costantini P,Druillennec S,Hoebeke J,Briand JP,Irinopoulou T,Daugas E,Susin SA,Cointe D,Xie ZH,Reed JC,Roques BP,Kroemer G |
|
Evidence
|
Abolition of Vpr52-96 homodimerization by replacement of two leucine residues by alanines (L60A L67A;reference 40) did not affect its apoptogenic function.
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HIV Mutation Detail Information