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Mutation Information
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Mutation Site
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L5M |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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X |
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Genotype/Subtype
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C |
Literature Information
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PubMed PMID
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33803998
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Published Year
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2021 |
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Journal
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Microorganisms |
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Title
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rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome. |
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Author
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Jeong H,Kim DH,Choi YM,Choi H,Kim D,Kim BJ |
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Evidence
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We also found that there are a total of 19 signature single nucleotide polymorphisms (SNPs), of which 2 and 17 nonsynonymous mutation types were specific to rt269L and rt269I, respectively: Of these, most are HBeAg negative infections (preC-W28*, X-V5M and V131I), lowered HBV DNA or virion production (C-I97F/L, rtM204I/V) or preexisting nucleot(s)ide analog resistance (NAr) (rtN139K/H, rtM204I/V and rtI224V) or disease severity (preC-W28*, C-I97F/L, C-Q182K/*, preS2-F141L, S-L213I/S, V/L5M, T36P/S/A, V131I, rtN139K/H, rtM204I/V and rtI224V).
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HBV Mutation Detail Information