|
Mutation Information
|
Mutation Site
|
L52A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV18 |
Literature Information
|
PubMed PMID
|
29630659
|
|
Published Year
|
2018 |
|
Journal
|
PLoS pathogens |
|
Title
|
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. |
|
Author
|
Morgan EL,Wasson CW,Hanson L,Kealy D,Pentland I,McGuire V,Scarpini C,Coleman N,Arthur JSC,Parish JL,Roberts S,Macdonald A |
|
Evidence
|
Expression of an E6 mutant unable to interact with E6AP (L52A) [42] impaired p53 degradation, but retained the ability to enhance STAT3 phosphorylation.
|
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HPV Mutation Detail Information