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HBV Mutation Detail Information

> L528M Search Result


Mutation Information
Mutation Site L528M
Mutation Type Amino acid level
Gene/Protein/Region Type P
Literature Information
PubMed PMID 21786803
Published Year 2011
Journal Journal of medicinal chemistry
Title Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
Author Yu W,Goddard C,Clearfield E,Mills C,Xiao T,Guo H,Morrey JD,Motter NE,Zhao K,Block TM,Cuconati A,Xu X
Evidence Standard molecular biology procedures employing the GeneTailor site-directed mutagenesis system (Invitrogen, Carlsbad CA) were used to generate single or double point mutations that give rise to the following amino acid changes in the polymerase open reading frame: A529V, N584T, M552I, M552V, L528M/M552V, and L528M/M552V/T532G/S550I.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation