HBV Mutation Detail Information

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Mutation Information

Mutation Site	L528M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	12526951
Disease	HBV infection
Published Year	2003
Journal	The American journal of gastroenterology
Title	Genotypic and phenotypic resistance: longitudinal and sequential analysis of hepatitis B virus polymerase mutations in patients with lamivudine resistance after liver transplantation.
Author	Ben-Ari Z,Daudi N,Klein A,Sulkes J,Papo O,Mor E,Samra Z,Gadba R,Shouval D,Tur-Kaspa R
Evidence	Sequential serum samples from 10 consecutive patients with lamivudine resistance after liver transplantation were analyzed for viral genotype, precore mutants, and viral polymerase gene mutants (L528M, M552V, M552I) using restriction fragment length polymorphism.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation