HBV Mutation Detail Information

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Mutation Information

Mutation Site	L528M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	11596084
Disease	HBV infection
Published Year	2001
Journal	Journal of medical virology
Title	Residual hepatitis B virus particles in liver transplant recipients receiving lamivudine: PCR quantitation of HBV DNA and ELISA of preS1 antigen.
Author	Petit MA,Buffello-Le Guillou D,Roche B,Dussaix E,Duclos-Vallée JC,Féray C,Samuel D
Evidence	Pol gene sequencing before andafter the breakthrough showed the selection of viralmutants in the catalytic site of the pol gene: M552V(YVDD) in patient 6, and M552I (YIDD) in patient 7 and another common mutation (L528M) in the Bdomain of the pol gene.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation