Mutation Information
Mutation Site
|
L528M |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
P |
Combined Mutation
|
p.M552V+p.M552I+p.L528M |
Viral Reference
|
X51970
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
PubMed PMID
|
11020004
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2000 |
Journal
|
Journal of hepatology |
Title
|
Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance. |
Author
|
Gutfreund KS,Williams M,George R,Bain VG,Ma MM,Yoshida EM,Villeneuve JP,Fischer KP,Tyrrel DL |
Evidence
|
In the majority of lamivudine-resistant isolates the mutations have been reported to occur within the YMDD motif of the viral polymerase, either as a single mutation M552I or as M552V concomitant with L528M.
|
|
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