HBV Mutation Detail Information

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Mutation Information
Mutation Site L528M
Mutation Type Amino acid level
Gene/Protein/Region Type P
Combined Mutation p.M552V+p.M552I+p.L528M
Viral Reference X51970
Relevant Drug lamivudine (LAM)
Literature Information
PubMed PMID 11020004
Disease Chronic hepatitis B
Published Year 2000
Journal Journal of hepatology
Title Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance.
Author Gutfreund KS,Williams M,George R,Bain VG,Ma MM,Yoshida EM,Villeneuve JP,Fischer KP,Tyrrel DL
Evidence In the majority of lamivudine-resistant isolates the mutations have been reported to occur within the YMDD motif of the viral polymerase, either as a single mutation M552I or as M552V concomitant with L528M.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation