Mutation Information
Mutation Site
|
L528M |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
P |
Combined Mutation
|
p.M552I+p.L528M |
Relevant Drug
|
lamivudine (LAM) |
Literature Information
PubMed PMID
|
10996115
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2000 |
Journal
|
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
Title
|
In vivo dynamics and pathogenicity of wild-type and resistant Hepatitis B virus during long-term lamivudine monotherapy - a clinical note. |
Author
|
Zöllner B,Stoehr A,Plettenberg A,Feucht H,Schröter M,Schäfer P,Laufs R |
Evidence
|
Nineteen weeks later, the virus exhibited additional resistance-associated mutations (L528M and I552V).
|
|
|