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Mutation Information
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Mutation Site
|
L528M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Combined Mutation
|
p.M552V+p.L528M;p.M552I+p.L528M |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10827158
|
|
Disease
|
HBV infection
|
|
Published Year
|
2000 |
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Journal
|
Hepatology (Baltimore, Md.) |
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Title
|
Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy. |
|
Author
|
Yeh CT,Chien RN,Chu CM,Liaw YF |
|
Evidence
|
Of the 23 patients included, 13 harbored either one or a mixture of the two common YMDD-motif mutants (methionine 552-to-isoleucine [M552I] and leucine 528-to-methionine/methionine 552-to-valine [L528M/M552V]) throughout the course, whereas in the remaining 10 patients, distinct mutants became dominant over the original mutants to cause continuing chronic hepatitis.
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HBV Mutation Detail Information