HBV Mutation Detail Information

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Mutation Information

Mutation Site	L528M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Combined Mutation	p.M552V+p.L528M
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	10679599
Disease	HBV-HIV coinfection
Published Year	2000
Journal	Gastroenterologie clinique et biologique
Title	[Emergence of resistant hepatitis B virus strains during long-term lamivudine therapy in human immunodeficiency virus co-infected patients].
Author	Rey D,Fritsch S,Schmitt C,Partisani M,Kempf-Durepaire G,Nicolle M,Krantz V,De Mautort E,Stoll-Keller F,Lang JM
Evidence	The 4 relapsers developed a double mutation Leu(528) for Met(528) and Met(552) for Val(552), on hepatitis B virus polymerase, either concomitant (M8 and M16) with a hepatitis B virus DNA increase, or 2 months earlier (M10 and M12).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation