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Mutation Information
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Mutation Site
|
L528M |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
P |
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Combined Mutation
|
p.M552V+p.L528M |
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Relevant Drug
|
famciclovir (FCV) |
Literature Information
|
PubMed PMID
|
10613749
|
|
Published Year
|
2000 |
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Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance. |
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Author
|
Xiong X,Yang H,Westland CE,Zou R,Gibbs CS |
|
Evidence
|
Several mutations (V521L, P525L, L528M, T532S, and V555I) in the gene for hepatitis B virus (HBV) polymerase have been identified in HBV isolated from patients that displayed break-through viremia during famciclovir treatment.
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HBV Mutation Detail Information