HBV Mutation Detail Information

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Mutation Information

Mutation Site	L528M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	famciclovir (FCV)

Literature Information

PubMed PMID	10589947
Disease	Chronic hepatitis B
Published Year	1999
Journal	Transplantation
Title	Famciclovir treatment of chronic hepatitis B in heart transplant recipients: a prospective trial.
Author	Wedemeyer H,Böker KH,Pethig K,Petzold DR,Flemming P,Tillmann HL,Vollmar J,Bastürk M,Goldmann E,Griffin KE,Haverich A,Manns MP
Evidence	Three patients developed virological breakthrough on famciclovir after 7, 8, and 26 months of treatment showing HBV-polymerase amino acid changes L528 M, S567A, and I581K, respectively.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation