HBV Mutation Detail Information

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Mutation Information

Mutation Site	L526M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Combined Mutation	p.M550I+p.L526M+p.L426I
Genotype/Subtype	C
Relevant Drug	hepatitis B immunoglobulin (HBIG);lamivudine (LAM)
Country	korea

Literature Information

PubMed PMID	12966541
Disease	Chronic hepatitis B
Published Year	2003
Journal	Journal of medical virology
Title	Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.
Author	Kim KH,Lee KH,Chang HY,Ahn SH,Tong S,Yoon YJ,Seong BL,Kim SI,Han KH
Evidence	These mutations caused L426I/L526M/M550I triple mutation (equivalent to L428I/L528M/M552I in previous reports) in the polymerase, and D144E mutation in the "a" determinant of HBsAg.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation