HBV Mutation Detail Information

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Mutation Information

Mutation Site	L526M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Combined Mutation	p.V553I+p.M550V+p.L526M;p.M550V+p.L526M+p.V519L;p.M550V+p.L526M
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	11886250
Published Year	2002
Journal	Virology
Title	Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapy.
Author	Torresi J,Earnest-Silveira L,Deliyannis G,Edgtton K,Zhuang H,Locarnini SA,Fyfe J,Sozzi T,Jackson DC
Evidence	HBsAg mutants including E164D, W196S, I195M, M198I, and E164D/I195M (corresponding to the polymerase protein changes of V519L, M550I, L526M/M550V V553I, and V519L/L526M/M550V) selected during lamivudine treatment also demonstrated reduced binding to anti-HBs antibody.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation