HBV Mutation Detail Information

> L526M Search Result

Mutation Information

Mutation Site	L526M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	famciclovir (FCV);lamivudine (LAM)
Country	china

Literature Information

PubMed PMID	11792996
Disease	Chronic hepatitis B
Published Year	2002
Journal	Transplantation
Title	Efficacy of famciclovir in the treatment of lamivudine resistance related to an atypical hepatitis B virus mutant.
Author	Tang S,Ho SK,Moniri K,Lai KN,Chan TM
Evidence	Treatment with famciclovir has not been effective in the majority of patients who developed lamivudine resistance due to methionine-to-valine mutation at position 550, because this mutation has been uniformly associated with leucine-to-methionine mutation at position 526, a mutation that is associated with resistance to famciclovir.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation