HBV Mutation Detail Information

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Mutation Information

Mutation Site	L526M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Genotype/Subtype	A
Relevant Drug	famciclovir (FCV);lamivudine (LAM);2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU)

Literature Information

PubMed PMID	11502520
Disease	Chronic hepatitis B
Published Year	2001
Journal	Antimicrobial agents and chemotherapy
Title	In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Author	Chin R,Shaw T,Torresi J,Sozzi V,Trautwein C,Bock T,Manns M,Isom H,Furman P,Locarnini S
Evidence	We found that the M550I and M550V plus L526M substitutions, which confer lamivudine resistance, did not confer cross-resistance to adefovir or DAPD, but conferred cross-resistance to L-FMAU.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation