|
Mutation Information
|
Mutation Site
|
L526M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10894274
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2000 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Evolution of lamivudine-resistant hepatitis B virus and HIV-1 in co-infected individuals: an analysis of the CAESAR study. CAESAR co-ordinating committee. |
|
Author
|
Pillay D,Cane PA,Ratcliffe D,Atkins M,Cooper D |
|
Evidence
|
HBV drug resistance mutations emerged in five of the 13 patients, four with L526M/M550V (in one of these cases an M550M/V and L526L/M mixture was noted) and one with M550I, however, their HBV viral load at week 52 remained a median of 40-fold lower than baseline values.
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HBV Mutation Detail Information