|
Mutation Information
|
Mutation Site
|
L526M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10449493
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
1999 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Hepatitis B virus (HBV) mutations associated with resistance to lamivudine in patients coinfected with HBV and human immunodeficiency virus. |
|
Author
|
Thibault V,Benhamou Y,Seguret C,Bochet M,Katlama C,Bricaire F,Opolon P,Poynard T,Agut H |
|
Evidence
|
In seven of these nine patients, Met(550), belonging to the highly conserved YMDD motif, was mutated to Val and was associated with a substitution of Met for Leu(526) in each case.
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HBV Mutation Detail Information