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Mutation Information
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Mutation Site
|
L523F |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Env |
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Viral Reference
|
K03455.1
|
|
Relevant Drug
|
VIR165 |
Literature Information
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PubMed PMID
|
30696772
|
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Published Year
|
2019 |
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Journal
|
The Journal of biological chemistry |
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Title
|
HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry. |
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Author
|
Eggink D,Bontjer I,de Taeye SW,Langedijk JPM,Berkhout B,Sanders RW |
|
Evidence
|
We found that most substitutions at position 515 and 523 were deleterious for viral infectivity, but substitutions I515F and I515T and to a minor extend L523F were viable with relative infectivities ranging from 4 to 32% compared with WT (Table 1, Fig.
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HIV Mutation Detail Information