|
Mutation Information
|
Mutation Site
|
L50G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
10400710
|
|
Published Year
|
1999 |
|
Journal
|
Journal of virology |
|
Title
|
The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300. |
|
Author
|
Zimmermann H,Degenkolbe R,Bernard HU,O'Connor MJ |
|
Evidence
|
An HPV-16 E6 mutant (L50G) that binds CBP/p300, but not E6AP, is still capable of down-regulating p53 transcriptional activity.
|
|
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HPV Mutation Detail Information