|
Mutation Information
|
Mutation Site
|
L49R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PreS1 |
|
Genotype/Subtype
|
E |
|
Country
|
Nigeria |
Literature Information
|
PubMed PMID
|
17503077
|
|
Disease
|
HBV associated liver disease
|
|
Published Year
|
2007 |
|
Journal
|
Medical microbiology and immunology |
|
Title
|
Hepatitis B virus genotype E surface antigen detection with different immunoassays and diagnostic impact of mutations in the preS/S gene. |
|
Author
|
Olinger CM,Weber B,Otegbayo JA,Ammerlaan W,van der Taelem-Brulé N,Muller CP |
|
Evidence
|
DNA positive samples with no detectable HBsAg or reduced HBsAg detection signals (<75% of mean signal obtained with HBsAg positive samples) revealed several mutations (V14A, F46S, N48T, L49R, I49T, D51G, A53V, P54L, Q82P, F83C, L127P, A184V, T189I, S204N, V224A), mostly outside the a-determinant.
|
|
|
HBV Mutation Detail Information