HIV Mutation Detail Information

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Mutation Information

Mutation Site	L449H
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag

Literature Information

PubMed PMID	19300491
Published Year	2009
Journal	PLoS pathogens
Title	Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss.
Author	Dam E,Quercia R,Glass B,Descamps D,Launay O,Duval X,Kräusslich HG,Hance AJ,Clavel F,ANRS 109 Study Group.
Evidence	Mutation I437V, immediately downstream of that cleavage site, was found in 2 viruses, and mutation L449H, at the P1 position of the SP2-p6 cleavage site was found in one virus, in association with the A431V mutation.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation