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Mutation Information
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Mutation Site
|
L441I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
L1 |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
31231420
|
|
Disease
|
Low grade squamous intraepithelial lesion;
High grade squamous intraepithelial lesion
|
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Published Year
|
2019 |
|
Journal
|
Frontiers in genetics |
|
Title
|
Abundance of HPV L1 Intra-Genotype Variants With Capsid Epitopic Modifications Found Within Low- and High-Grade Pap Smears With Potential Implications for Vaccinology. |
|
Author
|
Shen-Gunther J,Cai H,Zhang H,Wang Y |
|
Evidence
|
In addition to T353P, other mutations in this sample may lead to changes in the secondary structure, including W325C at G2 β-sheet, G367P at β-I sheet, T389S at α-2 helix, L441I at a β-turn, Q461P and F462Y near α-5 helix (Bishop et al., 2007).
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HPV Mutation Detail Information