HBV Mutation Detail Information

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Mutation Information
Mutation Site L426I
Mutation Type Amino acid level
Gene/Protein/Region Type P
Combined Mutation p.M550I+p.L526M+p.L426I
Genotype/Subtype C
Relevant Drug hepatitis B immunoglobulin (HBIG);lamivudine (LAM)
Country korea
Literature Information
PubMed PMID 12966541
Disease Chronic hepatitis B
Published Year 2003
Journal Journal of medical virology
Title Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.
Author Kim KH,Lee KH,Chang HY,Ahn SH,Tong S,Yoon YJ,Seong BL,Kim SI,Han KH
Evidence These mutations caused L426I/L526M/M550I triple mutation (equivalent to L428I/L528M/M552I in previous reports) in the polymerase, and D144E mutation in the "a" determinant of HBsAg.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation