HBV Mutation Detail Information

> L426I Search Result


Mutation Information
Mutation Site L426I
Mutation Type Amino acid level
Gene/Protein/Region Type P
Combined Mutation p.L426I+p.M550I
Genotype/Subtype C;adr
Relevant Drug lamivudine (LAM)
Country Japan
Literature Information
PubMed PMID 10502255
Disease Chronic hepatitis B
Published Year 1999
Journal Journal of medical virology
Title Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B.
Author Ogata N,Fujii K,Takigawa S,Nomoto M,Ichida T,Asakura H
Evidence In four patients, a substitution of valine or isoleucine for leucine at residue 426, which has not been reported previously, emerged in combination with M550I.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation