HIV Mutation Detail Information

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Mutation Information

Mutation Site	L363I
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag

Literature Information

PubMed PMID	32852081
Published Year	2020
Journal	The EMBO journal
Title	Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.
Author	Sumner RP,Harrison L,Touizer E,Peacock TP,Spencer M,Zuliani-Alvarez L,Towers GJ
Evidence	To test whether a CA-SP1 cleavage defect can cause HIV-1 to trigger innate sensing, we prepared chimeric VSV-G pseudotyped HIV-1 GFP viruses by transfecting 293T cells with varying ratios of WT HIV-1 GFP and HIV-1 GFP with CA-SP1 Gag mutant L363I M367I (Wiegers et al, 1998;Checkley et al, 2010).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation