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Mutation Information
Mutation Site L35P
Mutation Type Amino acid level
Gene/Protein/Region Type Tat
Country India
Literature Information
PubMed PMID 24465566
Disease HIV infection/AIDS
Published Year 2014
Journal PloS one
Title Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications.
Author Ronsard L,Lata S,Singh J,Ramachandran VG,Das S,Banerjea AC
Evidence Despite high amino acid conservation, some interesting mutations were observed in various functional domains which included K24T, H29Y and L35P mutations in cysteine-rich region with 1.000, 1.000 and 0.333 allelic frequencies respectively; G44S and S46F mutations in the core region with 30% and 20% of variants respectively; P68L mutation in all variants in the glutamine rich region which was neither seen with Tat B nor Tat C consensus sequences.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation