HIV Mutation Detail Information

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Mutation Information

Mutation Site	L33F
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Relevant Drug	darunavir (DRV)

Literature Information

PubMed PMID	27992544
Published Year	2016
Journal	PloS one
Title	Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.
Author	Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT
Evidence	This inactive protease with active site D25N mutation has 22 other mutations (L10I, V11I, L23I, V32I, L33F, S37N, M46I, I47V, I50V, F53L, I54V, Q58E, D60E, L63P, H69R, A71V, G73S, V77I, V82F, L89V, L90M, I93L) including 6 DRV resistance mutations (V11I, V32I, L33F, I47V, I50V, L89V).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation