HTLV1 Mutation Detail Information

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Mutation Information

Mutation Site	L319R
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tax
Combined Mutation	tax.L320S+tax.L319R

Literature Information

PubMed PMID	8970957
Published Year	1996
Journal	Journal of virology
Title	Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat.
Author	Tie F,Adya N,Greene WC,Giam CZ
Evidence	A dual amino acid substitution mutant of Tax, M47 (L319R, L320S), completely abrogated for activation of the human T-lymphotropic virus type 1 long terminal repeat as a result of a defect in the transactivation domain, continues to stimulate binding of bZip proteins to DNA.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation