HTLV1 Mutation Detail Information

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Mutation Information

Mutation Site	L319R
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tax
Combined Mutation	tax.L320R+tax.L319R

Literature Information

PubMed PMID	31299491
Published Year	2019
Journal	Virology
Title	The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.
Author	Malu A,Hutchison T,Yapindi L,Smith K,Nelson K,Bergeson R,Pope J,Romeo M,Harrod C,Ratner L,Van Lint C,Harrod R
Evidence	The diagram in Fig. 1B shows the sites of amino acid substitution mutations within Tax that impair CREB/ATF-dependent (M47: L319R; L320R; Smith and Greene, 1990) or NF-κB-dependent (M22: T130A; L131S; Smith and Greene, 1990, and G148V; Yamaoka et al., 1996) transactivation.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation