|
Mutation Information
|
Mutation Site
|
L303E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Rev |
Literature Information
|
PubMed PMID
|
28153748
|
|
Published Year
|
2017 |
|
Journal
|
Journal of molecular biology |
|
Title
|
A DEAD-Box Helicase Mediates an RNA Structural Transition in the HIV-1 Rev Response Element. |
|
Author
|
Hammond JA,Lamichhane R,Millar DP,Williamson JR |
|
Evidence
|
While many mutations, such as G325E, showed no noticeable change in binding affinity, two mutations, L303E (−RevA) and L322E (−RevB), showed significant decreases in Rev binding, with Kds of >700 and >500 nM respectively (Table 1).
|
|
|
HIV Mutation Detail Information