HPV Mutation Detail Information

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Mutation Information

Mutation Site	L294M
Mutation Type	Amino acid level
Gene/Protein/Region Type	E1
Genotype/Subtype	HPV16
Viral Reference	K02718.1
Country	Japan

Literature Information

PubMed PMID	24236186
Disease	High grade squamous intraepithelial lesion; Low grade squamous intraepithelial lesion; Cervical carcinoma
Published Year	2013
Journal	PloS one
Title	Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.
Author	Kukimoto I,Maehama T,Sekizuka T,Ogasawara Y,Kondo K,Kusumoto-Matsuo R,Mori S,Ishii Y,Takeuchi T,Yamaji T,Takeuchi F,Hanada K,Kuroda M
Evidence	The de novo assembled HPV16 genomes from clinical specimens revealed aa polymorphisms of the E1 protein in its DNA-binding domain at aa positions 294 and 326: a replacement of leucine (prototype) at position 294 with methionine (L294M) in 2 LSIL specimens (#3 and #4) and that of isoleucine (prototype) at position 326 with methionine (I326M) in all the specimens (Figure 5A).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation