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Mutation Information
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Mutation Site
|
L28F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E7 |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
AB818688
|
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
30995759
|
|
Disease
|
Cervical intraepithelial neoplasia;
Cervical carcinoma
|
|
Published Year
|
2019 |
|
Journal
|
Viruses |
|
Title
|
Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions. |
|
Author
|
Hirose Y,Onuki M,Tenjimbayashi Y,Yamaguchi-Naka M,Mori S,Tasaka N,Satoh T,Morisada T,Iwata T,Kiyono T,Mimura T,Sekizawa A,Matsumoto K,Kukimoto I |
|
Evidence
|
Out of the five SNPs, three led to amino acid changes of the viral proteins as follows: Leu to Phe at amino acid position 28 in the E7 protein, Ala to Thr at position 105 in the E2 protein, and Ser/Pro/Ala to Asp/Asn at position 269 in the L2 protein.
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HPV Mutation Detail Information