HPV Mutation Detail Information

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Mutation Information

Mutation Site	L28A
Mutation Type	Amino acid level
Gene/Protein/Region Type	E7
Genotype/Subtype	HPV16

Literature Information

PubMed PMID	16800784
Published Year	2006
Journal	Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Title	The human papillomavirus type 16 E7 protein binds human interferon regulatory factor-9 via a novel PEST domain required for transformation.
Author	Antonsson A,Payne E,Hengst K,McMillan NA
Evidence	Finally, we used alanine-scanning mutagenesis to determine if E7-IRF-9 interaction was important for E7-mediated cellular transformation and found that the HPV-16 E7 mutants Y25A, E26A, S31A, S32A, and E35A, but not L28A and N29A, caused loss of transformation ability.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation