HIV Mutation Detail Information

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Mutation Information

Mutation Site	L241A
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	32960169
Published Year	2020
Journal	eLife
Title	Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Author	Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB
Evidence	Virion morphology of a subset of IN mutants that inhibited vRNA interactions by three different mechanisms;that is, those that decreased IN levels in virions (N18I and W108R), those that may have directly inhibited IN binding to RNA (K34A, R262A/R263A), and those that primarily altered IN multimerization (E87A, E96A, F185K, R187A, L241A, L242A), was assessed by transmission electron microscopy (TEM).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation