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Mutation Information
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Mutation Site
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L23I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
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Relevant Drug
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atazanavir (ATV) |
Literature Information
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PubMed PMID
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29763303
|
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Published Year
|
2018 |
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Journal
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Journal of medicinal chemistry |
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Title
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Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. |
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Author
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Ghosh AK,R Nyalapatla P,Kovela S,Rao KV,Brindisi M,Osswald HL,Amano M,Aoki M,Agniswamy J,Wang YF,Weber IT,Mitsuya H |
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Evidence
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The amino acid substitutions identified in the protease-encoding region compared to the wild-type HIV-1NL4-3 were L23I, E34Q, K43I, M46I, I50L, G51A, L63P, A71V, V82A, T91A in HIV-1ATVR5μM; L10F, M46I, I54V, V82A in HIV-1LPVR5μM; or L10F, M46I, I50V, I85V in HIV-1APVR5μM.
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HIV Mutation Detail Information