HTLV1 Mutation Detail Information

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Mutation Information

Mutation Site	L235F
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tax

Literature Information

PubMed PMID	19356250
Published Year	2009
Journal	Retrovirology
Title	Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization.
Author	Zhang L,Zhi H,Liu M,Kuo YL,Giam CZ
Evidence	Many of these mutants, including L235F and A108T, remain capable of trans-activating both the HTLV-LTR-Luc and the NF-kappaB-Luc reporters, but are attenuated in induction of p21 and p27, and cell cycle arrest/senescence in HeLa cells.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation