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Mutation Information
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Mutation Site
|
L21W |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Country
|
China;Taiwan |
Literature Information
|
PubMed PMID
|
30771531
|
|
Disease
|
HBV infection
|
|
Published Year
|
2019 |
|
Journal
|
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases |
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Title
|
Diverse immune responses to HBV surface epitope variants after vaccine booster in adolescents immunized in infancy. |
|
Author
|
Lai MW,Liang KH,Yeh CT |
|
Evidence
|
The results showed SFCs per 106 PBMCs were 30.4 ± 4.3 (95% CI 18.4 to 50.4) for the wild type, 16.7 ± 5.5 (9.3–30.0) for R24K, 17.7 ± 4.2 (10.9–29.0) for L21W, 12.5 ± 7.1 (6.4–24.5) for L21S/R24K, and 16.7 ± 5.6 (9.3–30.1) for L21S/R24K/Q30L, indicating that IFN-γ-secreting cells were lower towards variants in this region, particularly for R24K and L21S/R24K variants (paired t-test, p < 0.01)
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HBV Mutation Detail Information