|
Mutation Information
|
Mutation Site
|
L21S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Viral Reference
|
AB697502;
AB246345;
JQ801515;
AB246346;
JQ801516;
AB246339;
AB900105;
AB246342 |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
30584239
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
Scientific reports |
|
Title
|
Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection. |
|
Author
|
Inuzuka T,Ueda Y,Arasawa S,Takeda H,Matsumoto T,Osaki Y,Uemoto S,Seno H,Marusawa H |
|
Evidence
|
Next, we also identified amino acid substitutions sL21S (n = 3) and sF220C (n = 4) in the MHC class II-restricted T-cell epitope region, which are reported to cause a complete loss of T-cell reactivity and anti-HBs production among individuals vaccinated against HBV in an ex vivo study
|
|
|
HBV Mutation Detail Information