HBV Mutation Detail Information

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Mutation Information

Mutation Site	L21S
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Genotype/Subtype	C
Country	China

Literature Information

PubMed PMID	27650283
Disease	HBV infection
Published Year	2017
Journal	Journal of hepatology
Title	Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
Author	Xiang KH,Michailidis E,Ding H,Peng YQ,Su MZ,Li Y,Liu XE,Dao Thi VL,Wu XF,Schneider WM,Rice CM,Zhuang H,Li T
Evidence	In-depth data mining (Fig. 1C) revealed previously identified immune escape mutations within the ‘a’ determinant region (sS117T, sK122R, sI126N/S/T, and sG145R), carboxyl terminal truncation mutations (sC69* and sW182*) and additional rarely described mutations (sE2G, sL21S, sR24K, sT47K/A, sL95W and sL98V).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation