HBV Mutation Detail Information

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Mutation Information

Mutation Site	L21F
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Genotype/Subtype	C
Viral Reference	AB014394.1
Country	Japan

Literature Information

PubMed PMID	29434654
Disease	Hepatocellular carcinoma; Occult HBV infection
Published Year	2018
Journal	Infectious agents and cancer
Title	Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.
Author	Hatazawa Y,Yano Y,Okada R,Tanahashi T,Hayashi H,Hirano H,Minami A,Kawano Y,Tanaka M,Fukumoto T,Murakami Y,Yoshida M,Hayashi Y
Evidence	The minor populations of variants harbouring the W4R, L30S, Q118R/Stop, N123D and S124F/P mutations in the pre-S region and the L21F/S and L42F/S mutations in the S region were detected more frequently in OBI-related HCC than in HBsAg-positive HCC.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation