|
Mutation Information
|
Mutation Site
|
L21A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Viral Reference
|
AF038399.1
|
Literature Information
|
PubMed PMID
|
32272714
|
|
Published Year
|
2020 |
|
Journal
|
Molecules (Basel, Switzerland) |
|
Title
|
Recent Advances in HIV-1 Gag Inhibitor Design and Development. |
|
Author
|
Dick A,Cocklin S |
|
Evidence
|
Site-directed mutagenesis and PI[4,5]P2 SPR-based competition assay confirmed the PI[4,5]P2 binding site as the interaction site for Compound 7, and accordingly, mutations such as L21A and T81A in a pseudotyped virus lost susceptibility to the compounds tested.
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HIV Mutation Detail Information